Liverpool can take another giant step towards just a second English top-flight title in 35 years against fragile Manchester City on Sunday as Ruben Amorim aims for a first Premier League win as Manchester United manager.
Liverpool are the only team with a perfect record in this season's Champions League after beating title-holders Real Madrid 2-0 in their heavyweight clash on Wednesday, with last season's runners-up Borussia Dortmund among the night's other winners.
Manchester City's struggles continued as Pep Guardiola's side remarkably blew a three-goal lead to draw 3-3 with Feyenoord in the Champions League on Tuesday, while Bayern Munich beat Paris Saint-Germain to leave the French club in danger of elimination.
Arne Slot can seemingly do no wrong as Liverpool manager but uncertainty over the futures of Mohamed Salah, Virgil van Dijk and Trent Alexander-Arnold is casting a shadow over a spectacular season.
With Real Madrid's Vinicius Junior injured for the Champions League clash at Liverpool on Wednesday, superstar summer signing Kylian Mbappe will become their key attacking weapon.
Bayern Munich host Paris Saint-Germain on Tuesday in a battle between two sides flying high domestically but seemingly struggling to adjust to the new Champions League format.
Pep Guardiola said he expected a slip in Manchester City's standards sooner or later but even he has been shocked by the English champions' implosion in a five-game losing streak.
New Manchester United manager Ruben Amorim said he is the right man to revive the ailing English giants' fortunes ahead of his debut against Ipswich on Sunday.
Pep Guardiola has extended his contract as manager of Premier League champions Manchester City for a further two seasons, saying Thursday "I could not leave now" with the club facing arguably the toughest period of his time at the Etihad Stadium.
Chelsea eased into the Women's Champions League quarter-finals on Wednesday with a 3-0 win over Celtic, while Lyon and Real Madrid also booked their places in the knockout phase.